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Artikel: Measuring Individual Burden of Illness for Depression among prostate cancer patients

Abstract: This study aims to develop and test three potential models of Individual Burden of Illness for Depression (IBI-D) in prostate cancer patients.

Methods: Responses to three sets of scales measuring depressive symptoms, functional impairment, and quality of life satisfaction were collected from 191 prostate cancer patients and analysed via prin- cipal components analysis to obtain weightings for each of the scales within the three sets of measures. These weightings were then used to form IBI-D Indices, and these were then compared with depres- sive symptoms alone for their overlap.

Results: Single-factor solutions were found for each of the three IBI-D models, demonstrating gen- eralizability across the three models. Equations based on the loadings of each scale within each IBI-D model, divided by the standard deviation of total IBI-D scores, were used to form IBI-D Indices. Although the correlations between the Patient Health Questionnaire-9 (PHQ9) and each of these IBI-D Indices were statistically significant, between one-quarter and one-fifth of the variance in IBI-D Indices was not accounted for by PHQ9 score alone, demonstrating that the IBI-D Indices provided ad- ditional information above that obtainable from a measure of depression alone.

Conclusions: The IBI-D Index can be used to more completely assess the overall effects of depres- sion in prostate cancer patients, the associations between those effects and predictor variables, and the outcomes of intervention studies aimed at decreasing depression (and its effects) in these men. 

Auteur: 
Christopher F. Sharpley, Vicki Bitsika and David R. H. Christie
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